The devastating consequences of climate change, ecosystem degradation, biodiversity loss, and pollution have never been more severe for health than today. Heat, epidemics, food insecurity, water scarcity, natural disasters that are increasing in intensity, frequency and duration are major challenges that threaten health and well-being at a global scale, while health systems around the world remain unprepared. To move forward, different UN agencies and cross-sectoral stakeholders have to jointly address ongoing and emerging crosscutting issues, taking into account the interactions between climate change, biodiversity loss, and health at all stages of the negotiation process. Despite its potential, a health-focused framing in current climate discussions is not yet sufficiently applied. For the first time a health day at the COP28 will pave the way to focus on the health-climate interface and a set of solutions that need to be addressed, which will reshape the governance and the economics of global climate and health policy while putting a focus on an equity-based approach. This means pro-actively including Planetary Health and One Health approaches in international collaborative mitigation and adaptation strategies and creating a common narrative and vision. Next steps will have to include the construction of climate-resilient and sustainable low carbon health systems that consider the health sector as a guide in shaping an effective response to environmental health challenges.