G20 Global Health Summit-Australia

Ligand-based drug design is a computational approach used in the development of new drugs. It involves designing molecules that can bind to a specific target protein or receptor by using information about the ligand (small molecule) that binds to the target. Ligand-based drug design offers advantages such as the ability to design drugs for targets with known ligands, computational efficiency, and the potential for identifying novel chemical scaffolds. However, it relies on the availability of high-quality data on ligands and requires validation through experimental studies. It is often used in combination with other drug design approaches, such as structure-based drug design, to maximize the chances of success in discovering new therapeutic agents.