Pharmaceutical manufacturing, a factor of the pharmaceutical business, is the procedure of synthesising pharmaceutical medications on an industrial scale. A number of entity operations, including milling, granulation, coating, tablet pressing, and others, can be used to breakdown the drug production process into its component parts. Dry ice can be used in a lab to cool a reaction selectively, but on an industrial scale, this procedure becomes complex. It is expensive to chill a normal reactor to this temperature, and as the temperature drops, the viscosity of the reagents often rises as well, making mixing challenging. This results in a non-homogeneous reaction or higher expenditures from having to stir more vigorously and replace pieces more frequently.